http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0572122-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f84747e8d08b1023763356d0e7d1db68 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-51 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-51 |
| filingDate | 1993-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_419c2f22fdee731427dea406e9ae274b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99ca1346bcb4e8de23503c5aa4ce7a3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_063e7a0e7c5cd261e0dd88cc7643e70d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_061843e211bfa923679365f8a4c98c8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9eca94e06423668d7745e193399d435d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8881ac94cfd4ec970f167e55d03fb7d2 |
| publicationDate | 1993-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0572122-A2 |
| titleOfInvention | C-terminal modified osteogenic growth polypeptides |
| abstract | The invention relates to a polypeptide which binds to naturally occurring osteogenic growth-polypeptide binding protein/s (OGPBP) and does not bind to an antibody directed against said naturally occurring osteogenic growth polypeptide (OGP), said OGPBPs being proteins which bind to the N-terminal region of OGP and to analogues thereof. n Preferred polypeptides according to the invention are those in which the C-terminal region is modified to prevent binding of the polypeptide to an antibody directed against OGP. n The invention also relates to a method of releasing an immunoreactive OGP from its complex with OGPBPs wherein the said complex is reacted with a polypeptide according to the invention, whereby the immunoreactive OGP is competed out of said complex by the polypeptide according to the invention. n The invention further relates to a method of quantitatively determining the total immunoreactive OGP content in a sample of a biological fluid or tissue extract and to a method for the determination of the binding capacity of OGPBPs. n The methods of the invention are useful for diagnosing pathological conditions associated with abnormal binding capacity of OGPBPs by measuring the said binding capacity. n The invention also relates to pharmaceutical compositions containing as active ingredient polypeptides according to the invention. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9732594-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7189692-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9420529-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5814610-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6479460-B1 |
| priorityDate | 1992-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 225.