| abstract |
The present invention relates to essentially pure dimers of apolipoprotein Al-Milano, (Apo Al-M / Apo Al-M) isolated and characterized from plasma for the first time. The invention also relates to pharmaceutical compositions containing this Apo Al-M / Apo Al-M. The apolipoprotein Al-M dimer is obtained from a recombinant Escherichia coli system or collected from a plasma of apolipoprotein Al-Milano vectors. The invention also relates to a method of treating atherosclerosis and cardiovascular disease and to the use of the dimer in the preparation of a medicament. The medicament containing this dimer can be used for the treatment of atherosclerosis and cardiovascular diseases and for the prevention of thromboses, in various clinical situations, at arterial level as at venous level. This dimer can also serve as a prodrug for the monomer. |