| abstract |
Disclosed are benzothiophene and thienothiophene derivatives useful for inhibiting urokinase activiy. Novel components of the formula :n nwherein R 1 is H, NH 2 , or a halogen ;n each R 2- R 5 , independently, is a H, halogen, hydroxy, amino, nitro or organic group, provided that at least one R 2- R 5 is an organic group which includes 5 carbons or greater, an organic group which contains a sulfur atom or hydroxy, an unsaturated organic group, or a cyclic organic group ; and each R 6 and R 7 , independently, is H or a straight chain alkyl group of between 1 and 6 carbons of the formula :n nwherein R 1 is H, NH 2 , or a halogen ; each R 2- R 5 , independently, is a H, halogen, hydroxy, amino, nitro, or organic group, provided that at least one of R 2- R 5 is a group other than H, OH, NO2, CN, a halogen, an alkyl group of between 1 and 4 carbons, an alkoxy group of between 1 and 4 carbons, a haloalkyl group of between 1 and 4 carbons, a haloalkoxy group of between 1 and 4 carbons, an amino group, an amino group substituted with an alkyl group of between 1 and 4 carbons, a nitrile group, or a carboxamidine group, and further provided that no two adjacent R 2- R 5 groups together form a methylenedioxy group ; and each R 6 and R 7 , independently, is H or a straight chain alkyl group of between 1 and 6 carbons and of the formula :n nwherein at least one of X, Y, or Z must be C ; at least one of X, Y, or Z must be O, N, or S ; and, if more than one of X, Y, or Z is O, N, or S, then at least one of those groups is N ; R 1 is H, NH 2 , or a halogen ; each R 2 , R 3 , or R 5 , independently, is a H, halogen, or organic group ; and each R 6 and R 7 , independently, is H or a straight chain alkyl group of between 1 and 6 carbons are described. |