| abstract |
A process of optically resolving an optically active platinum complex compound consisting of a mixture of a d-isomer and an I-isomer uses high performance liquid chromatography employing a column packed with a chiral filler. n The chiral filler may be, for example, a cellulose ester derivative, a cellulose carbamate derivative, an amylose carbamate derivative, a polymethacryl acid ester andβ-and-γ-cyclodextrin. n An optically pure cis-oxalato (trans-1-1,2-cyclohexanediamine) Pt(II) separated from a d-isomer by the process of the invention is found to be remarkably effective as a raw material for preparing a carcinostatic agent. n Complete optical purity of the compound reflects in a lower melting point of the substance as compared with that of an impure substance. |