| abstract |
This invention relates to N-[2-amino-4-substituted-[[(pyrrolo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acid compounds of formulan whereinn Ar is dihydropyrrolo, pyrrolo, pyrido or tetrahydropyrido ; R 1 is hydrogen, chloro, alkylthio, alkoxy, alkylamino, or dialkylamino ; and R 2 is C 2 -C 3 alkyl intermediates for their synthesis, pharmaceutical formulations containing those compounds, and their use as antineoplastic agents. |