http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0565620-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0fc2a22a9271507062ad7e07974d3c58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 1992-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3eebf55525633ddf08c4fec4ecf1a05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5119f1f6ee478dc27cc0c51d0109230 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec1e1137b0fb67d8a07d13deb85dbe1b |
| publicationDate | 1993-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0565620-A1 |
| titleOfInvention | MITOTOXIN FOR TREATMENT OF VESSEL DAMAGE. |
| abstract | Patients with vascular lesions caused by the use of a balloon catheter or the like are treated with drugs containing conjugates comprising a ligand such as fibroblast base growth factor (bFGF) (or another fibroblast growth factor polypeptide), and a cytotoxic agent. The cytotoxic agent may consist of a ribosome inactivation protein (RIP), such as saporin, and is attached to the ligand via a chemical bond or prepared as a DNA chimera of recombination. The drug containing the conjugate is administered intravenously to patients after they have been treated for atherosclerosis in a manner that frequently causes vascular damage, particularly to the intima, this drug effectively preventing restenosis . The ligand binds to and activates high affinity bFGF receptors, these receptors being surprisingly expressed on smooth muscle cells in the lumen of blood vessels, thereby allowing the cytotoxic agent to penetrate target cells and eventually destroy unwanted proliferating cells. |
| priorityDate | 1991-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 156.