| abstract |
The invention relates to the use of peptide derivatives for the manufacture of endopeptidase inhibitor drugs 24.15 and 24.16.n n n These peptide derivatives correspond to the formula: in which R 1 is an optionally substituted aralkyl group, R 2 is Pro, Hyp, thiazolidine or dehydroproline, R 3 is H or an alkyl radical, R 4 is an alkyl group or the side chain of an amino acid, R 5 and R 6 may be H, NH4 or metals, and R 7 is H or CH 3 .n n n Examples of effective derivatives are N- (phenylethylphosphonyl) -Gly-Pro-aminohexanoic acid and N- (phenylethylphosphonyl) -Ala-Pro-aminohexanoic acid. |