| abstract |
There are new oxyalkynes of the general formula I in which the meta or para substituent Y R¹ CH₃ or NH₂, R² H or CH₃ and R³ H, C₁₋₃ alkyl or COCH₃ and Ar is an aromatic radical from the group with the proviso that the substituents R⁴, R⁵ and R⁶ are the same or different and each represent H, F, Cl, Br, C₁₋₆-alkyl, CF₃ or C₁₋₆-alkoxy and R⁷ is H, F, Cl, Is Br, C₁₋₃ alkyl or CF₃, described as racemates or diastereomer mixtures or in optically active form and a process for their preparation. The oxyalkines inhibit 5-lipoxygenase or 5- and 12-lipoxygenase and are used as medicines. |