| abstract |
Disclosed is a non-naturally occurring fusion protein comprising an extender peptide portion having at its C-terminus a covalent bond to the N-terminus of a biologically active portion. The extending peptide portion can be removed by cleavage by dipeptidylpeptidase IV (DPP IV). The invention also relates to the use of fusion proteins having extension peptide parts cleavable by DPP IV, in medical preparations. A method for purifying the desired proteins from a mixture containing a fusion protein is also described. |