http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0561861-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97764a207c7d2b88edea0656b0669d7c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-554 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-10 |
| filingDate | 1991-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1995-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de572409a58456d4888fb3cd0281f98d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0412433c7aca08862240cf8545380a1e |
| publicationDate | 1995-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0561861-B1 |
| titleOfInvention | A process for the preparation of diltiazem |
| abstract | PCT No. PCT/EP91/02353 Sec. 371 Date Jun. 23, 1993 Sec. 102(e) Date Jun. 23, 1993 PCT Filed Dec. 9, 1991 PCT Pub. No. WO92/10485 PCT Pub. Date Jun. 25, 1992.(+)-Cis-3-(acetoxy)-5-[2-(dimethylamino)-ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride is prepared by N-alkylation of (+)-cis-3-hydroxy-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one with dimethylaminoethyl chloride and K2CO3 in toluene/water, addition of a solubilizing agent and in the presence of a phase-transfer catalyst, the toluene phase being directly subjected to the final O- acetylation. |
| priorityDate | 1990-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.