| abstract |
Transgenic model for selective targeting of a gene product by means of a megakaryocyte promoter, linked to a gene encoding the product, and recombination product comprising the megakaryocyte promoter and the gene. The expression of the gene product has been shown to be limited to platelets and megakaryocytes in the bone marrow. It has been shown, in particular, that the promoter of the antiheparinic factor (4) (PF4) causes the targeting of the expression of a gene on the platelets, the megakaryocytes of the bone marrow and, moreover, the adrenal glands. |