| abstract |
The compounds are of the general formulan n orn n where R₁ is -OH, amino or -SH, R₂ is H, α- or β-naphthyl or optionally substituted phenyl, R₃ is mono-, di- or tricycloalkyl of C6-16, optionally substituted, R₄₋₇ are H or alkyl, R₈₋₉ are alkyl or may form a 6-membered ring or a 5-membered ring with R₆ and R₇, R₁₀ and R₁₁ are alkyl, and n is 0 or an integer. n Synthesis examples are given, and for the preparation of starting materials. n Pharmaceutical compositions for oral, topical or injectable administration contain the compounds or their acceptable salts. n The compounds have excellent antiviral activity as illustrated against herpes virus and may also be effective against influenza, DNA, RNA and HIV viruses. |