| abstract |
We proposed a novel compound having an activity of PGI₂ receptor agonist. n A phenoxyacetic acid derivative of the formulan n A is -C(R¹ )=N∼OR², -CH(R)NH-OR², -COE, -SO₂E, -CH₂-NR³-Y, -Z-NR³-CONR⁴R⁵, -CH₂-OR⁶, -CO₂R⁶, -CH₂-O∼N=CR⁷R⁸, -CH₂-O-NHCHR⁷R⁸, substituted by imidazolyl(methyl), pyrazolylmethyl, oxazolyl(methyl), thioxazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolylmethyl; nT is alkylene, alkenylene, etc.; nD is -CO₂R¹⁰, -CONR¹¹R¹²; nE is (substitution) amino, hydradino; nY is substituted (thio) carbonyl, substituted sulfonyl; nZ is -CH=N-, -CH₂NR³-; nR¹, R³, R¹⁰-R¹³ is each H or alkyl, etc. ; nR², R⁴-R⁹ is each H, alkyl or alkyl substituted by phenyl or hetero ring, etc. and non-toxic salts thereof, non-toxic acid addition salts thereof, possess an agonistic on PGI₂ receptor, so it is useful for prevention and/or treatment of thrombosis, arteriosclosis, ischemic heart diseases, gastric ulcer and hypertension. |