| abstract |
New derivatives of azabicycloalkane-1 and their stereoisomers corresponding to the general formula (I), in which R1 represents a phenyl, substituted phenyl, naphthyl or thienyl group, where the phenyl group may be substituted by one or more halogen atoms or methyl, methoxy, methylthio or trifluoromethyl groups; R2 represents a hydrogen atom or a C2-5 aliphatic acyl group; R3 represents a hydrogen atom or a methyl group; n can be 0 or 1; the dotted line may optionally represent an additional C-C bond and the wavy line means that the respective substituent may be bonded to the carbon atom at either of the two steric positions; as well as their pharmaceutically acceptable acid addition salts. A process for the preparation of the aforementioned compounds and pharmaceutical compositions containing them has also been provided. The compounds corresponding to general formula (I) exhibit valuable therapeutic activity, mainly anti-amnesic. |