http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0555537-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5dfc0b033ac4c841466d97a5f28ea32b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0808 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0812 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06017 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0202 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-087 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 |
| filingDate | 1992-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb65713e5426353ada9ed800a03700b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb9ef5e1130623f41d912d9f53fe576c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31b39b8e01b3a268508acd43b44c7513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67c402d4ba20b3a472a321362308e931 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ceb5a44eebaa73e21866b413bde59e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b213facadd1790ac89268104f44d52b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5516ad49b0b0a74e4b2bd568c153adf |
| publicationDate | 2000-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0555537-B1 |
| titleOfInvention | Endothelin antagonists |
| abstract | A peptide derivative of the formula: <CHEM> wherein A is a group of the formula R<1><1>O-CO- (wherein R<1><1> is a lower alkyl group or a phenyl group), or a group of the formula R<1><2>R<1><3>N-C(=O)- (wherein R<1><2> is a lower alkyl group, a cycloalkyl group, a 1-adamantyl group, a phenyl group wherein one or two optional hydrogen atoms on the benzene ring may independently be replaced by a halogen atom, a trifluoromethyl group, a nitro group, an amino group or a formylamino group, a pyridyl group, or a thienyl group, R<1><3> is a hydrogen atom, a lower alkyl group or a cycloalkyl group, or R<1><2> and R<1><3> form, together with the adjacent nitrogen atom, a 5- to 9-membered nitrogen-containing saturated heterocyclic ring having 4 to 8 carbon atoms, wherein among methylene groups forming the ring, one optional methylene group not adjacent to the above nitrogen atom may be replaced by a thio group, and one to four optional hydrogen atoms on the carbon atoms of the heterocyclic ring may independently be replaced by a lower alkyl group, and further two adjacent carbon atoms in the heterocyclic ring may form a benzo-fused ring); B is an oxygen atom or a group of the formula -NR<2>- (wherein R<2> is a hydrogen atom or a lower alkyl group); R<3> is a lower alkyl group, a cycloalkyl group, an aryl group, a heterocyclic group, a cycloalkyl lower alkyl group, an aryl lower alkyl group or a heterocyclic lower alkyl group; X<1> is an oxygen atom or a group of the formula -NR<4>- (wherein R<4> is a hydrogen atom or a lower alkyl group); R<5> is a 3-indolylmethyl, 3-benzothienylmethyl, 1-naphthylmethyl or benzyl group wherein one or two optional hydrogen atoms on the ring may be replaced by a hydroxyl group, a halogen atom, a formyl group, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower alkylsulfinyl group, a lower alkylsulfonyl group, a lower alkoxycarbonyl group, a nitro group or a group of the formula R<5><1>-CO-X<2> {wherein R<5><1> is a lower alkyl group, a lower alkoxy group, or an amino group which may be substituted by a lower alkyl group, and X<2> is an oxygen atom or a group of the formula -NR<5><2>- (wherein R<5><2> is a hydrogen atom or a lower alkyl group)}; X<3> is an oxygen atom or a sulfur atom; R<6> is a hydrogen atom, or a lower alkyl or lower alkenyl group which may have a substituent selected from the group consisting of a hydroxyl group, a lower alkoxy group, a lower alkylthio group and a heterocyclic group; n is 0 or 1; Y is a hydroxymethyl group, a group of the formula CO2R<7><1> (wherein R<7><1> is a hydrogen atom or a lower alkyl group), a group of the formula CONHR<7><2> (wherein R<7><2> is a hydrogen atom or a lower alkyl group which may have a substituent selected from the group consisting of a hydroxyl group, a carboxyl group and a sulfo group), a 1H-tetrazol-5-yl group, a sulfo group and a phosphono group; or a pharmaceutically acceptable salt thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9446011-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7446115-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9095557-B2 |
| priorityDate | 1991-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 539.