| abstract |
A novel thiazole derivative represented by general formula (I), which has a selective agonistic activity for 5-HT₃ receptor, a pharmaceutical composition thereof, and a process for producing the same. In the said formula, R¹ represents hydrogen or lower alkoxy; R² and R³ are such that R² represents hydrogen and R³ represents a group, -Y-Het, wherein Y represents a single bond or lower alkylene and Het represents a nitrogenous heterocyclic group, or alternatively R² and R³ are combined together to form a group, -(CH₂) m -NR⁴-(CH₂) n -, wherein m and n are each 1 or 2 and R⁴ represents lower alkyl; and X represents -NH-, -NHC(=O)NH-, -C(=O)NH- or -NHC(=O)-. |