| abstract |
A platelet aggregation inhibitor useful as an antithrombotic, composed of a synthetic cyclic pentapeptide containing the tripeptide sequence Lys-Gly-Asp and a thioether bond in the cycle. A preferred platelet aggregation inhibitor is represented by formula (I), wherein R1 and R9 represent OH; R2, R4, R5, R6, R7, R8 and R14 represent hydrogen; R3 and R4 are linked to form a pyrrolidine ring; X represents sulfur; m is 1 and n is 3. |