| abstract |
The invention concerns oxime derivatives of the formula In n wherein R⁴ includes hydrogen, carboxy, carbamoyl, amino, cyano, trifluoromethyl, (1-4C)alkylamino, di-(1-4C)alkylamino and (1-4C)alkyl; nR⁵ includes hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, (2-5C)alkanoyl, halogeno-(2-4C)alkyl and hydroxy-(2-4C)alkyl; nAr¹ is phenylene or a heteroaryl diradical; nA¹ is a direct link to X¹, or A¹ is (1-4C)alkylene; nX¹ is oxy, thio, sulphinyl or sulphonyl; nAr² is phenylene or a heteroaryl diradical; nR¹ is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; and nR² and R³ together form a group of the formula -A²-x²-A³- which together with the carbon atom to which A² and A³ are attached define a ring having 5 or 6 ring atoms, wherein each of A² and A³ is (1-3C)alkylene and X² is oxy, thio, sulphinyl, sulphonyl or imino; nor a pharmaceutically-acceptable salt thereof; nprocesses for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors. |