| abstract |
A new polypeptide, called neurotrophic factor-4 (NT-4), was identified by amplification using the polymerase chain reaction of human genomic DNA. A nucleic acid encoding NT-4 is described which is useful for diagnostics and for the recombinant preparation of NT-4. Further described are nucleic acids encoding naturally occurring NT-4 amino acid sequence variations, which are called NT-4beta, NT-4gamma and NT-4DELTA. The neurotrophic factors of the present invention are useful for the treatment of nerve cells and for diagnostic studies. |