| abstract |
A novel protein of human origin produced by a human ovarian tumor established cell line HUOCA-II or HUOCA-III, which has a molecular weight, when determined by SDS-polyacrylamide gel electrophoresis, of from 72,000 to 80,000 daltons under a non-reducing condition or from 79,000 to 85,000 daltons under a reducing condition, which contains an amino acid sequence represented by the Sequence ID No. 4 deduced from the DNA sequence represented by the Sequence ID No. 5, and which enhances growth of vascular endothelial cells but does not activate growth of smooth muscle cells, fibroblasts and hepatocytes and also does not enhance or inhibit growth of HeLa cells. This invention also provides a process for the production of the protein. |