| abstract |
Novel tricyclic compounds and salts are disclosed useful as AII receptor antagonists. These are compounds of the formula I and their salts:n R1 represents hudrogen, halogen or C 1 -C 6 alkyl; n A represents cyano, carboxyl, tetrazolyl, cyano-substituted phenyl, carboxyl-substituted phenyl or tetrazolyl-substituted phenyl; n V represents -(CH 2 ) m -, where m is 0,1 or 2; n W represents a group of the formula α, β, γ or δ n where α is:n where R 2 , R 3 and R 4 are each hydrogen, halogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, halogenated C 1 -C 6 alkyl, hydroxy, C 1 -C 6 alkoxy, amino, C 1 -C 6 alkylamino, carboxyl or C 1 -C 6 alkoxycarbonyl; and Q 1 -Q 2 -Q 3 -Q 4 represents N=CH-CH=CH, CH=CH-CH=CH or CH 2 -CH 2 -CH 2 -CH 2 : n β is:n wherein R 2 , R 3 and R 4 are as defined above: n γ is:n where R 5 and R 6 each represent hydrogen, C 1 -C 6 alkyl or C 3 -C 6 cycloalkyl, and R 7 represents carboxyl, C 1 -C 6 alkoxycarbonyl, carbamoyl or hydroxymethyl; and n δ is:n where R 8 and R 9 each represent hydrogen or C 1 -C 6 alkyl, and Q represents N or CH; n X 1 -X 2 -X 3 represents the group CH=CH-CH=CH, S-CH=CH or CH=CH-S; n Y represents a single bond, CH 2 , O, S, CH 2 O, OCH 2 , CH 2 S, SCH 2 , CH 2 CH 2 or CH=CH; and n Z 1 -Z 2 represents the group C=CH, CH-CH 2 , CH-CH(COOH)- or N- (CH 2 ) n - (wherein n is an integer of 1 to 3). |