http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0548217-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_568bb9260a9dfbb7fb7959be6161ab94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8735e0be68446d0c834f9355e747aa55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b2f4f4fcdd64cc67aeaa65ceac95a179 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-003 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 |
| filingDate | 1991-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1997-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f425e475cc23f3d9eea72826c604740d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e7d99b472b9402ed36ab6b62de7b80d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99a4536f7faab96c21519b848ccaac06 |
| publicationDate | 1997-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0548217-B1 |
| titleOfInvention | Process for the preparation of c-terminally amidated peptides |
| abstract | Preparation of C-terminally amidated peptides P-NH2 by reacting a substrate component selected from a) C-terminally unblocked peptides P-OH, b) peptides or peptide derivatives P-X-Y, where X is an amino acid or peptide residue and Y is OH, OMe or C-terminal modification, and c) C-terminally esterified peptides P-OR', where R' is alkyl, aryl, heteroaryl, aralkyl or an alpha -des amino fragment of an amino acid, with a nucleophile component in the presence of an enzyme using as nuclophile a compound NH2-R capable of cleaving the reaction product P-NH-R to P-NH2, and undertaking such cleavage. Preferred nucleophiles are selected from (I), wherein A-F and A'-E' are carbon atoms or up to two hetero atoms, Y is H, alkyl, aryl, aralkyl, oxo or carboxy, or a functional derivative thereof, X<1>-X<5> are H or various substituents. The cleavage may be induced by photolysis, solvolysis, reduction, rearrangement elimination or oxidation. The process is very flexible in that it may be adapted to any type of enzymatic synthesis and lend itself to C-terminal amidation of all types of peptides. |
| priorityDate | 1990-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 382.