| abstract |
The present invention relates to new pyridyl derivatives of the general formula in the R₆ is a pyridine group optionally substituted in the 3- or 4-position by an alkyl group, and X, Y, A, n and R₃ to R₆, R₇ and R₈ are as defined in claim 1, their enantiomers, their cis and trans isomers, if provided R₄ and R₅ together represent a carbon-carbon bond, which have valuable properties. The compounds of the general formula I above, In R₇ represents a cyano group and Y represents an alkoxy, phenoxy, alkylthio or phenylthio group Intermediates and the other connections have valuable ones pharmacological properties, in particular antithrombotic effects, moreover, the new compounds simultaneously represent thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH) and thus also inhibit the effects mediated by thromboxane. Furthermore, these also have an effect on PGE₂, production in the lungs and on PGD₂, PGE₂ and PGF₂α production in human platelets. |