http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0546742-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_046e16bd6918ef3cd62184605b15a413 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-08 |
| filingDate | 1992-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d2988eefe998cf162a3e4deba589edb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a48a3f3f8e8ece7b3faf422d70fd682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5fb63434c60db5d598d3009a0e409f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ff753f73ca3f3b68439f69c88d89baf |
| publicationDate | 1993-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0546742-A1 |
| titleOfInvention | 4-(1,1-Dialkoxycarbonyl-alkyl)azetidin-2-one-derivatives and synthesis of 4-(1-carboxy-alkyl)azetidin-2-one derivatives therefrom |
| abstract | A 4-(1,1-dialkoxycarbonylalkyl)azetidin-2-one derivative is of the formula:n nwhere R 1 and R 2 each represents alkyl, alkenyl or aralkyl (preferably both are 2-alkenyl), R 3 represents CI-4 alkyl, R 4 represents hydrogen or a hydroxyl-protective group, e.g., tri-substituted silyl, acyl or aralkyl, and R 5 represents a hydrogen atom or an amino-protective group e.g., tri-substituted silyl, aralkyl or alkoxyalkyl. Synthesis when R 5 is H is from a malonic acid derivative R 3- COOR I .COOR 2 and a 4-acetoxyazetidin-2-one derivative; and when R 5 is a protective group the thus produced compound is reacted,e.g. with a tri-substituted silyl chloride so as to incorporate such groups. n For synthesis of a 4-(1-carboxyalkyl)azetidin-2-one derivative (II)n nwhere R 3 represents a CI-4 alkyl and R 4 represents hydrogen or a hydroxyl-protective group, the compound (I) is de-esterified and decarboxylated (I), and when an amino-protective group is present in (I), this group is then eliminated. n The products (II), especially those having a β-configuration alkyl group, are useful as an intermediate for 1β-alkylcarbapenem-type antibacterials and can thus be produced efficiently on an industrial scale. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0589626-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5700931-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0671398-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0671398-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5654424-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014089810-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0638552-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6242596-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101479281-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0638552-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5550230-A |
| priorityDate | 1991-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 141.