| abstract |
The invention relates to novel and newly developed non-natural dipeptoid pro-drugs of alpha-substituted TRp-Phe derivatives which are useful as agents for the treatment of obesity, hypersecretion of gastric acids in the body. intestine, gastrin-dependent tumors, or as neuroleptics. These dipeptoids can also serve as anxiolytics and anti-ulcer agents. They are useful in preventing the reaction to stopping chronic nicotine, diazepam, alcohol, cocaine, caffeine or opioid treatment or chronic use of these substances. These pro-drugs are also useful in the treatment and / or prevention of panic attacks. The present invention also describes pharmaceutical compositions and methods of treatment which use these prodrugs, as well as methods of preparing these prodrugs and new intermediates useful in their preparation. Another feature of the present invention is the use of these prodrug compounds in diagnostic compositions. |