| abstract |
This invention relates to novel trans cyclopentanyl purine analogs of the formula (1)n n wherein n the substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative to the bicyclic substituent, n Y₃, Y₅ Y₇, Y₈ and Y₉ are each independently nitrogen or a CH group, n R is a hydrogen, a C₁-C₇ alkyl acyl or aryl acyl, n Q is NH₂, halogen or hydrogen, n Z is hydrogen, halogen, or NH₂; nor a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants. |