abstract |
Conjugated medicinal agent prepared by the combination of asialoglycoprotein with a drug acting specifically on the liver. Said conjugated medicinal agent corresponds to formula (I): P (S) x-Gal-GA-R, in the fraction P- (S) x of which P represents a peptide residue of a human serum glycoprotein; Gal represents a residue of Galactose; GA represents a residue of glutaraldehyde; x is an integer equal to or greater than 1; and R represents a medicinal constituent selected from the group consisting of interferon, acyclovir sodium, vidarabine, azidothymidine, suramin, antisense oligonucleotide, ribozyme, leukovorin calcium, sodium diatrizoate-meglumine, gadolinium-DTPA, glutathione (GSH), prostaglandins, 99mTc and 131I. There is also provided a process for preparing the conjugated medicinal agent of formula (I), a pharmaceutical composition containing the conjugated medicament, as well as the use of said conjugated medicament. |