| abstract |
The invention relates to the use of a nucleotide analog of formula (I) in which R1 represents (i) a hydrogen atom, (ii) a residue of 2 'or 3'-P-thionucleotidyl conjugated in its position 5 'to an acyl group, (iii) a phosphoryl group, a P-thiophosphoryl group, a PO2R2H group optionally esterified with a linear or branched, cyclic or acyclic aliphatic hydroxy alkyl group, consisting of 1 to 6 carbon atoms or with a lipophilic moiety, or (iv) an acyl group; R2 represents a C1C6 alkyl group or a hydrogen atom, and the pharmaceutically acceptable salts thereof, in the manufacture of a medicament which can be used as an antiviral agent, an antitumor, an immunomodulator, an interferon stimulator or an interferon inducer . Certain compounds of formula (I) are new. A process for their preparation and pharmaceutical compositions containing them are also described. |