http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0541654-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_571b8abacacea64d3f7089d0983b8b3b |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-086 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
filingDate | 1991-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64dc777cfb7b757b45de8ad0ffe8c6af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4839c29b90a8104c4129a3654aedd91 |
publicationDate | 1993-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-0541654-A1 |
titleOfInvention | Bombesin antagonists |
abstract | The invention describes a polypeptide corresponding to formula (I) XX1TrpX2X3X4X5X6X7NH2, in which X represents a group X8Arg (or D-Arg) X9X10 and X8 represents dis NH2Pro, TyrPro, Dis NH2TyrPro, Ada, Pro, D-Pro or is deleted ; X9 represents Gly, Ala, D-Ala or is deleted; X10 represents Asn, Phe, D-Phe or Phe or D-Phe substituted by one or more halo atoms; or X represents a group A- (CH2) n-CO- in which A represents a group containing from 1 to 3 rings, at least one of which is aromatic, each ring system being optionally substituted; and the alkylene group is optionally substituted with one to four groups selected from amino, hydroxy, C1-4alkoxy and C1-4alkyl optionally substituted with halo and n is between 0 and 4; or X represents a cyclopentyl carbonyl substituted by a group X8Arg (or D-Arg) X9X10 defined as above; X1 represents His, ThiAla or is deleted; X2 represents Ala, D-Ala, CPenc, D-tBuGly or Pro; X3 represents Val or Val substituted by one or more halo atoms; X4 represents Gly, Ala, D-Ala, Sarcosine, Pro, D-Pro or D-Phe; X5 represents His or ThiAla; X6 represents D-Propsi, Propsi, 2-pyrrolidinyl-3-hydroxypropionyl or D-Pro; X7 represents Nle, Leu, Phe, Val, Mox, D-Phe, Phe or D-Phe substituted by one or more halo or naphthylAla or naphthyl D-Ala atoms or a hydrophobically substituted aromatic amino acid or aralkylamine, or is deleted. The invention also describes the salts of said polypeptide acceptable in pharmacology. These polypeptides have properties of antagonism to bombesin-like peptides and are effective in the treatment of malignant diseases. |
priorityDate | 1990-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 463.