http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0539976-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 |
| filingDate | 1992-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d22f0df95f2b38d643eebc6f76abbdfe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71be0e7597065b65410354ec5439d26f |
| publicationDate | 1993-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0539976-A1 |
| titleOfInvention | Ethynyl-alanine-amino-diol compounds for treatment of hypertension |
| abstract | Compounds characterized generally as ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula In n wherein A is selected from CO and SO₂ wherein X is selected from oxygen atom and methylene; wherein each of R₁ and R₉ is a group independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, benzyl, b, b, b-trifluoroethyl, t-butyloxycarbonyl and methoxymethylcarbonyl, and wherein the nitrogen atom to which R₁ and R₉ are attached may be combined with oxygen to form an N-oxide; wherein R₂ is selected from hydrido, methyl, ethyl and isopropyl; wherein R₃ is selected from benzyl, cyclohexylmethyl, phenethyl, imidazolemethyl, pyridylmethyl and 2-pyridylethyl; wherein R₅ is propargyl or a propargyl-containing moiety; wherein R₇ is cyclohexylmethyl; wherein each of R₄ and R₆ is independently selected from hydrido and methyl; wherein R₈ is selected from ethyl, n-propyl, isobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclohexylmethyl, cyclohexylethyl, allyl, vinyl and fluorovinyl; wherein each of R₁₁ and R₁₂ is independently selected from hydrido, alkyl and phenyl; wherein m is zero; and wherein n is a number selected from zero through three; or a pharmaceutically-acceptable salt thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9404508-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9404536-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-669005-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5373017-A |
| priorityDate | 1991-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 552.