| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e3bbcd3ff80c4cd20f176bc993d15a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5fea07a86b723a789f5dac6fc8e79b9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-726
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70571
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate |
1991-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8dee6e77625b806a9e1d73d874d40a1c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9520ffa79bbacefdc1eca63aba588c74 |
| publicationDate |
1993-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0539518-A1 |
| titleOfInvention |
Methods of identifying compounds that act as agonists or antagonists for proteins involved in signal transduction |
| abstract |
The method described, which is used to identify a chemical which acts as an agonist on a cell surface receptor coupled to the G protein (GPC receptor), consists in introducing into the test cells a line of pigment cells capable of dispersing or aggregate their pigment in response to a specific stimulus and express an exogenous clone encoding the GPC receptor, a stimulant which establishes an initial state of pigment disposition in which the pigment is aggregated inside the test cells if activation of the exogenous GPC receptor induces a dispersion of the pigment or to introduce a stimulant which establishes an initial state of disposition of the pigment in which the pigment is dispersed inside the test cells if activation of the exogenous GPC receptor induces an aggregation of the pigment; contacting the test chemical with the test cells placed in an initial state of arrangement of the pigment; and determining whether the arrangement of the pigment in the test cells treated with the chemical has changed from the initial state of the arrangement of the pigment, any change in the arrangement of the pigment observed in the test cells which express the receptor Exogenous GPC indicating that the chemical is an agonist for the exogenous GPC receptor. |
| priorityDate |
1990-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |