| abstract |
1R-cis isomer, 1'R-cis of a 2 ', 2' salt - (3,11-dioxo-4,10-dioxatridecylene) -bis- (1,2,3,4-tetrahydro-6,7 -dimethoxy-2-methyl-1-veratrylisoquinolinium), practically devoid of other geometric and optical isomers of this salt. The 1R-cis, 1'R-cis isomer has been shown to have an advantageous combination of pharmacological features, including greater neuromuscular blocking potency, reduced histamine releasing potency, and, at neuromuscular blocking levels equivalent, less potential adverse effects on the autonomic nervous system (sympathetic and parasympathetic blockage) compared to the known mixture of geometric and optical isomers. |