| abstract |
(I) Compounds ofgeneral formula (I)n n wherein; nR¹ represents a group selected from CH₂CONR⁴R⁵, XYR⁶, phenyl, C₃₋₇-cycloalkyl or C₁₋₆alkyl, optionally substituted by a hydroxy, phenyl, C₁₋₆alkoxycarbonyl, C₃₋₇cycloalkyl or adamantyl group; nR² represents a group selected from NR⁷SO₂CF₃, SO₂NR⁷COR⁸, CONR⁷SO₂R⁸, nor a tetrazole, carboxamidotetrazole, or 3-trifluoromethyl-1,2,4-triazole group in which the tetrazole or triazole moiety may be substituted on one of the nitrogen atoms by a C₁₋₄alkyl group; nR³ is phenyl optionally substituted by one or two halogen atoms; nR⁴ and R⁵ which may be the same or different each independently represent a hydrogen atom, or a phenyl or C₁₋₄alkyl group or NR⁴R⁵ represents a saturated 5- to 7- membered nitrogen containing heterocyclic ring, optionally substituted by 1 or 2 methyl groups; nR⁶ represents a group selected from C₁₋₆alkyl, optionally substituted phenyl, C₃₋₇cycloalkyl or adamantyl; nR⁷ represents hydrogen or a C₁₋₄alkyl group; nR⁸ represents a C₁₋₄alkyl group, nX is a C₁₋₃ straight or branched alkylene chain; nY represents a group selected from -C=O, C(OR⁹)₂ or C(SR⁹)₂ wherein R⁹ is C₁₋₃alkyl or the two R⁹ groups together form a C₂₋₄alkylene chain; nn is zero or 1; are modulators of gastrin and or CCK. |