| abstract |
A tetrahydroprotoberberine quaternary ammonium compound represented by the general formula:n n R,R',X are as defined in the specification. Protoberberine is reduced by potassium borohydride to tetrahydroprotoberberine (I). Tetrahydroprotoberberine quaternary ammonium compounds are prepared by reaction of tetrahydroprotoberberine with halohydrocarbon in acetone or ethanol. These compounds can suppress arrhythmia and ventricular fibrillation, protect myocardial is chemia, and can be conveniently orally administered. |