| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f4246e8fcebf17c365aced017a04c61 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate |
1991-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6def67a083ec8bed6af3a06d50c5e01d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8857da1328a894136a42f4e3da44b9b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df59c625e4b46851433b11bfe3c28521 |
| publicationDate |
1993-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0538534-A1 |
| titleOfInvention |
Improved process for chemical reactions on camptothecin or analogs thereof |
| abstract |
A process for preparing a reduced camptothecin derivative in which a camptothecin substrate bearing a reducible substituent is hydrolyzed under alkaline conditions to open the lactone E ring and form a carboxylate salt. The carboxylate salt is reduced to form a reduced carboxylate salt which is then contacted with acid to reform the lactone E ring. This procedure results in substantially increased yields of camptothecin derivatives. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9419353-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005063211-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5731316-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102574866-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6352996-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1547582-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5608066-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6156897-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6407239-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6403603-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6107486-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6218399-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6228855-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6120793-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102574866-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6407118-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005063211-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1393719-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6096336-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5527913-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004002454-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9504736-A1 |
| priorityDate |
1987-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |