| abstract |
A compound for use as a medicine having formula (I), a pharmaceutically acceptable acid addition salt form or a stereochemically isomeric form thereof, wherein R?1 and R2¿ each independently are hydrogen, C¿1-6?alkyl or C3-6cycloalkyl; or R?1 and R2¿ taken together with the nitrogen atom bearing said R?1 and R2¿ may form a pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl or 4-C¿1-4?alkylpiperazinyl group; X is O or S; R?3¿ is hydrogen or C¿1-6?alkyl; R?4, R5 and R6¿ each independently are hydrogen, halo, C¿1-6?alkyl, C1-6alkyloxy, nitro, trifluoromethyl, cyano, aminomethyl, carboxyl, C1-4alkyloxycarbonyl, C1-4alkyl-carbonyl, aminocarbonyl or hydroxy; R?7¿ is hydrogen or halo; and R?8, R9 and R10¿ each independently are hydrogen, halo, C¿1-6?alkyl, C1-6alkyloxy, nitro, hydroxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, (trifluoromethyl)carbonyl, aminocarbonyl, (cyclopropyl)carbonyl or a radical C1-6alkyl-(C=Y)- wherein =Y represents =O, =N-OH, =N-OCH3, =N-NH2 or =N-N(CH3)2; provided that (1) R?1¿ is other than n-propyl when R?2, R3, R4, R5, R6, R7, R9 and R10¿ represent hydrogen, R8 represents 4-ethoxy and X represents oxygen, and (2) X is other than sulfur, when R?1, R2, R3, R6, R7, R8, R9 and R10¿ represent hydrogen and R?4 and R5¿ represent 3,4-dimethoxy. Novel compounds, pharmaceutical compositions containing said compounds of formula (I), and processes for preparing said compositions. |