http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0535548-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3cd3ea6c52ef8544c67c051a2ef489b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2baf849d216e689ecc40ccc931a7a7bc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 1992-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5cca0195549ee0bb05bd79099625deb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a67783af9d7b1af2a71399f289ff665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecfd5a0e62b0ab5e79a99da4b23ef1d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_900de754437df25e0060c2e3797b8aef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03f9758565367d202a9f74156f4f1ee8 |
| publicationDate | 2001-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0535548-B1 |
| titleOfInvention | Inhibitor of atherosclerotic intimal thickening |
| abstract | An inhibitor of atherosclerotic intimal thickening, which contains an effective amount of a compound of the formula (I): <CHEM> wherein ring X is phenyl, substituted phenyl or 5- or 6-membered heterocyclic aryl; each of R<1> and R<2> which are independent of each other, is hydrogen, C<5> PI 3/4 alkyl, C<7> PI 1/2 cycloalkyl, C<5> PI <7> alkoxy, n-butoxy, i-butoxy, sec-butoxy, tert-butoxy, R<2>0R<2><1>N- (wherein each of R<2>0 and R<2><1> which are independent of each other, is hydrogen or C<5> PI <7> alkyl), trifluoromethyl, trifluoromethoxy, difluoromethoxy, fluoro, chloro, bromo, phenyl, phenoxy, benzyloxy, hydroxy, trimethylsilyloxy, diphenyl-tert-butylsilyloxy, hydroxymethyl or -O(CH<6>)POR<2><2> (wherein R<2><2> is hydrogen or C<5> PI <7> alkyl, and P is 1, 2, or 3); or R<1> and R<2> together form -CH=CH-CH=CH- or methylenedioxy, when they are at the o-position to each other; R<3> is hydrogen, C<5> PI 3/4 alkyl, C<6> PI 1/4 alkenyl, C<7> PI 1/2 cycloalkyl, C psi PI 1/2 cycloalkenyl or <CHEM> (wherein R7 is hydrogen, C<5> PI 3/4 alkyl, C<5> PI 3/4 alkoxy, C<5> PI <7> alkylthio, chloro, bromo, fluoro, chloromethyl, trichloromethyl, trifluoromethyl, trifluoromethoxy, trichloromethoxy, difluoromethoxy, phenoxy, benzyloxy, hydroxy, trimethylsilyloxy, diphenyl-tert-butylsilyloxy or hydroxymethyl); or C<5> PI <7> alkyl substituted by one <CHEM> (wherein R7 is as defined above) and zero, one or two C<5> PI <7> alkyl; Y is -CH<6>-, -CH<6>CH<6>-, -CH=CH-, -CH<6>-CH=CH-, -CH=CH-CH<6>-, -C(CH<7>)=CH- or -CH=C(CH<7>)-; Z is -Q-CH<6>-W-CH<6>-CO<6>R<1><2>, <CHEM> (wherein Q is -C(O)-, -C(OR<1><3>)<6>- or -CH(OH)-, W is -C(O), -C(OR<1><3>)<6>- or -C(R<1><1>)(OH)-, R<1><1> is hydrogen or C<5> PI <7> alkyl, R<1><2> is hydrogen, R<1>4 (wherein R<1>4 is alkyl of a chemically or physiologically hydrolyzable alkyl ester moiety, NHR<2><3>R<2>4R<2>5 (wherein each of R<2><3>, R<2>4 and R<2>5 is hydrogen or C<5> PI <8> alkyl), sodium, potassium or 1/2 calcium), each R<1><3> is independently primary or secondary C<5> PI 1/4 alkyl, or two R<1><3> together form -(CH<6>)<6>- or -(CH<6>)<7>-, and each of R<1>5 and R<1>6 which are independent of each other, is hydrogen atom or C<5> PI <7> alkyl, or R<1>5 and R<1>6 together form -(CH<6>)<6>- or -(CH<6>)<7>-. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104031034-A |
| priorityDate | 1991-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 334.