| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb8f3eba86915d967beefc175437273a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed28726de9f916f355f8adc331e736b8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2035-124 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-503
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0669
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1825
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0663
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-50 |
| filingDate |
1991-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4fdef2a52677745534e43783e3d7ac59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b235071eb21a3b921515afc09c70189
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55319701155bf8e438576a4007568477 |
| publicationDate |
1993-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0535148-A1 |
| titleOfInvention |
Stimulation of bone marrow stromal and progenitor cells |
| abstract |
The basic fibroblast growth factor (bFGF) is used in vitro to stimulate the production of large quantities of bone marrow stromal cells, which are useful as feeder cells to generate hemopoietic parent cells in cultured bone marrow. Basic FGF is also used directly in a complete bone marrow culture to increase the number of parent hemopoietic cells. Bone marrow cells produced in culture under the influence of bFGF are used in autologous or allogeneic bone marrow transplantation. In order to speed up the rate of bone marrow transplantation, bFGF is administered with one or more colony stimulating factors to a bone marrow transplant recipient. In another method, or additionally, bFGF is administered to a bone marrow donor in order to increase the concentration of hemopoietic parent cells present in the given bone marrow. BFGF is also administered to patients with an aplastic condition to stimulate endogenous cytokines such as colony stimulating factors and interleukins. |
| priorityDate |
1990-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |