| abstract |
This invention relates to human growth hormone (hGH) mutants in which the amino acid residue arginine (Arg) in position 134 of the natural hGH amino acid sequence is substituted with an amino acid residue chosen from the group consisting of L-alanine (Ala), L-leucine (Leu). L-threonine (Thr), L-phenylalanine (Phe), L-proline (Pro) and L-histidine (His), and means and methods for their preparation. n These mutants demonstrate a better stability towards enzymatic degradation than natural hGH and unaltered biological activity. The mutants can be used in the therapeutic field for treating dysfunctions of the hypophysis, and in the cure of pathological states such as burns, dystrophy, pseudoartrosis and bone fractures. |