| abstract |
The composition and methods of synthesis of several prodrugs are described. These methods can be used to transform drugs with negative charge phosphorus into prodrugs soluble in neutral charge lipids, which can passively diffuse into cells and through biological membranes. The invention also relates to prodrugs for a variety of anti-viral and anti-leukemic agents. In addition, the invention relates to a class of prodrugs degraded by an elimination reaction to form a carbon-carbon double bond. The elimination reaction is triggered by an esterase. |