http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0533752-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_634715a790f7ef0163a61e9f364bebcd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-68 |
| filingDate | 1991-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0fd9896771eb233fcd0b33a8a15f5ad |
| publicationDate | 1998-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0533752-B1 |
| titleOfInvention | Improved method for synthesis |
| abstract | The present invention relates to an improved method for the synthesis of omeprazole, comprising the steps of reacting 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-1H-benzimidazole with m-chloroperoxy-benzoic acid in a methylene chloride solution at a substantially constant pH of about 8.0 to 8.6; extracting the reaction mixture with aqueous NaOH; separating the aqueous phase from the organic phase; and adding an alkyl formate to the aqueous phase, resulting in crystallization of omeprazole. |
| priorityDate | 1990-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.