http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0531305-A4
Outgoing Links
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|---|---|
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| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D67-0093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-0029 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-0005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-3673 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-0047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D67-00931 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D67-00933 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-0094 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D67-009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-1678 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D69-127 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M1-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D69-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G77-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M1-16 |
| filingDate | 1991-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1993-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0531305-A4 |
| titleOfInvention | Gas permeable thrombo-resistant coatings and methods of manufacture |
| abstract | The present invention is directed to thrombo-resistant coatings for use with gas permeable biomedical devices and implants. The coatings include a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A quantity of at least one bioactive molecule designed to counteract a specific blood-material incompatibility reaction is covalently bonded to the poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is preferably achieved by plasma etching with ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a solution of at least one bioactive molecule which counteracts a blood-material incompatibility reaction, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface is capable of resisting blood-material incompatibility reactions while maintaining high gas permeability. |
| priorityDate | 1990-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.