http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0530537-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5929f2d6f4dba84be8dd3a8ba633db12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 1992-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1997-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b92f2b95300101f155294eb099c73496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89a7d92f97e9e412bfbaecc2c16cacf3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1ed78d8bf32485961b0147b7af8b61c |
| publicationDate | 1997-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0530537-B1 |
| titleOfInvention | Condensed pyrimidine derivatives, their production and use as antitumor agents |
| abstract | A condensed pyrimidine derivative of the formula (I): <CHEM> wherein the ring A stands for an optionally substituted 5-membered ring; B stands for an optionally substituted divalent 5- or 6-membered homo- or hetero-cyclic group; X stands for, among others, amino group; Y stands for, among others, hydrogen atom, halogen atom or amino group; Z stands for a divalent aliphatic group having five or less atoms forming straight chain, optionally having nitrogen, whose chain portion may optionally have a hetero-atom; W stands for, among others, -NH-CO-or -CO-NH-; R<1> stands for an optionally substituted cyclic or chain-like group ; COOR<2> stands for an optionally esterified carboxyl group; and p denotes an integer of 1 to 4, provided that when -W-R<1> denotes a moiety represented by the formula: <CHEM> wherein COOR<1><6> and COOR<1><7> are, independently, an optionally esterified carboxyl group and n denotes an integer of 1 to 5, p denotes 1, 3 or 4, or a salt thereof, exhibiting highly specific toxicities to various tumor cells and excellent therapeutic effects on methotrexate-resistant tumor cells as well. |
| priorityDate | 1991-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1292.