| abstract |
In order to obtain new non-ionic monomeric and dimer radiographic contrast agents with very good water solubility and reduced osmotic pressure, methylene groups are introduced into the side chains of triodized benzoic acid or isophthalic acid. triode. The invention further relates to a process for the preparation of these compounds, according to which a triodized 5-acyl-amido-2,4,6-isophthalic acid amide or a 3,5-diacylamido- 2,4,6-benzoic acid triod or a 3,5-diacylamido-2,4,6-benzoic acid triod with an alkylating agent having the formula X-(CH2)n-R3, in a basic medium, X denoting in the formula a halogen, a sulphonic acid ester or a usual leaving group. |