| abstract |
The invention relates to transgenic rats, in the genome of which at least one human gene, the gene product of which is involved in blood pressure regulation, is integrated. The invention further relates to transgenic rats and their offspring which have elevated blood pressure (> 90 /> 140 mm Hg) or high blood pressure (> 95 /> 160 mm Hg). Finally, the invention relates to processes for the production of the transgenic rats according to the invention and their progeny and their use for pharmacological studies. |