http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0527185-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73e1811d43cc130de2daafc08fecf8eb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-405 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D475-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 |
| filingDate | 1991-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c4d9bf600e5a074013ac0d572a61502 |
| publicationDate | 1993-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0527185-A1 |
| titleOfInvention | Amethopterin precursors (methotrexate) intermediates, processes for their preparation and compositions containing them. |
| abstract | The present invention relates to the synthesis of gem-diphosphonic analogs of amethopterin (methotrexate), and their use as pharmaceutical compositions, for various therapeutic applications. The objective is in particular to associate the concept of prodrug with the pharmacological vectorization of antineoplastic agents with respect to bone carcinomas, by diphosphonic acids. According to the invention, the gem-diphosphonic compounds of amethopterin (methotrexate) and of deaza N-10 amethopterin are in the form of an amethopterin prodrug whose gem-diphosphonic group is linked to the pteroylglutamic group by a peptide bond . These compounds are in particular usable in pharmaceutical compositions for oncology, in particular for the treatment of tumors or metastases in particular bone, and / or rheumatology, in particular for the treatment of rebellious psoriatic arthritis, polymyositis, Reiter's disease and polyarthritis rheumatoid. |
| priorityDate | 1990-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.