| abstract |
A pharmaceutical compund having the Formula:n n where: n R is C₅-C₇ cycloalkyl, heterocycle, aryl or unsaturated heterocycle; n X is a bond, (-CH₂) q -, -O-(-CH₂-) q -, -(-CH₂-) q -O-or -N(R⁵)(CH₂-) m -; n n is 0, 1, or 2; n q is 1, 2, 3 or 4; n R¹ is aryl or C₅-C₇ cycloalkyl; n R² is an amino acid side chain, unsaturated heterocycle, unsaturated heterocycle(C₁-C₄ alkanediyl), C₁-C₄ alkylaminocarbonyl(C₁-C₄ alkanediyl), or a group having the structure -CH₂-C(O)-NR⁴-X-R or -CH₂-R; n Y is an aryl or unsaturated heterocycle; n R³ is a group having the structure: nn 1) -C(O)-NR⁴R⁴ 2)n 3)n 4)n 5)n 6)n n where: n 1 is 3, 4 or 5; n m at each occurrence is independently 0, 1, 2, or 3; n p is 4 or 5; n R⁴ at each occurrence is independently hydrogen, C₁-C₆ alkyl, or hydroxy(C₁-C₄)alkanediyl; n R⁵ and R⁶ are independently selected from hydrogen, hydroxy, C₁-C₆ alkyl, C₁-C₆ alkoxy, amino, C₁-C₄alkylamino, hydroxy (C₁-C₄) alkanediyl, carboxy, (C₁-C₄alkoxy)carbonyl, aminocarbonyl, C₁-C₄ alkylaminocarbonyl, aryl, heterocycle or unsaturated heterocycle; nor a pharmaceutically acceptable salt or solvate thereof. |