| abstract |
The invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof in which: R1 represents -CH3 or -CH2CH3 substituted or unsubstituted, by 1 to 3 fluors, X represents O or S (O) where s = 0 to 2; R2 represents C4-C6 cyclic alkyl, optionally substituted by one to three methyl groups or an ethyl group; -CH2-cyclopenthyle, -CH2-cyclopropyle, 3-tétrahydrofuranyl, C1-7 alkyl, CH3 or CH2CH3 substituted by one to three fluors; - (CH2) nCOO (CH2) gCH3, or (CH2) nO (CH2) gCH3, where n represents 2 to 4 and g represents 0 to 2; R3 represents a fraction of formula (a); wherein R4 and R5 each represent hydrogen or R4 and R5 together represent a bond; B represents> C = O,> C = S or> CH-R6 where R6 represents H, OH, C1-6 alkoxy or C1-6 thioalkoxy; and m and r each independently represent zero or an integer between 1 and 4, where m + r represents an integer between 2 and 4; provided that when R1 represents methyl, X represents oxygen, R2 represents methyl or cyclopenyl, and R3 does not represent cyclopent-1,2-ene-3-one. |