| abstract |
Compounds of benzylated O6-guanine, guanosine and 2'-deoxyguanosine corresponding to formula (I), where Z represents hydrogen, (alpha) or (beta), and R represents a benzyl group or a substituted benzyl group, causing depletion of the activity of O6-alkylguanine-DNA alkyltransferase (AGT) in mammalian cells. These compounds can be administered to a host to reduce levels of AGT in host tumor cells to increase the host's sensitivity to antineoplastic alkylating agents, including chloroethylene agents, such as chloroethylnitrosoureas. , to treat a number of neoplasms with chemotherapy. |