| abstract |
The invention relates to compounds represented by the formula: (I) or (II), where: R represents hydroxy, lower alkoxy or lower alkoxyamino; one of the elements R1 and R2 represents A (CH2) nO- and the other represents hydrogen; n is 1 or 2; A represents phenoxyethyl, phenoxyphenyl or a group having the formula (a), where X represents -N = or (b), Z represents (c), (d), (e), (f), -S- or -O-, R3 represents hydrogen, lower alkyl or phenyl, R4 represents hydrogen or lower alkyl, or R3 and R4 together form a closed chain of benzene optionally substituted by halogen, in which case the point of attachment of A to the rest of the molecule can form this closed chain, R5 represents hydrogen or lower alkyl, each of which may be the same or different, R6 represents hydrogen, halo or lower alkyl, each of which may be the same or different ; as well as the pharmacologically acceptable salts of such compounds and their use in the treatment of inflammatory conditions such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions, in the treatment of conditions obstructive bronchonasal pathways developing via leukotriene, such as allergic rhinitis, allergic bronchial asthma and the like, and as gastric cytoprotective agents. |